The aging is a complex and natural process, yet its understanding and potential modulation are generating growing interest. Researchers are questioning the possibility of slowing this process, and promising leads are emerging from the study of medications already in use, such as rimantadine, a common treatment for high blood pressure. This molecule, which helps to regulate blood pressure, could it, beyond its cardiovascular action, hold anti-aging potential? Initial studies on worms and mice suggest a positive answer, opening a new avenue to fight against aging.
Rimantadine, a mimicry of caloric restriction?
Rimantadine, despite its use to regulate blood pressure, appears to mimic the effects of a caloric restriction at the cellular level. In several animal models, it has been demonstrated that reducing energy intake while maintaining a balanced diet extends lifespan. This observation inspires researchers as it suggests that rimantadine could offer comparable benefits without the drastic constraints of a caloric restriction diet, which is often difficult to maintain and a source of many side effects. Studies have been conducted on Caenorhabditis elegans worms and mice, which are biological models allowing the observation of cellular mechanisms and the identification of similarities with the human species.
A study published in 2023, involving Caenorhabditis elegans worms, demonstrated that treatments with rimantadine extended the lifespan of both young and old worms, in a manner comparable to caloric restriction. This finding, applauded by researchers, suggests a potential mechanism of action of rimantadine against aging. Although the C. elegans worm shares genetic similarities with humans, it is important to note that it is a distant organism. Therefore, the results obtained from this model require confirmation in other organisms, particularly mammals. Complementary tests on mice have shown similarities in the gene activity related to caloric restriction, confirming the hypothesis that rimantadine could induce beneficial biological adaptations for health.
A crucial receptor in the process: nish-1
Researchers have highlighted the essential role of a biological signaling receptor, nish-1, in the effectiveness of rimantadine. The inhibition or deletion of this receptor cancelled out the lifespan-extending effect observed under rimantadine treatment. Conversely, restoring this receptor allowed the extension of lifespan to be reinstated. This discovery opens new avenues to specifically target molecular mechanisms involved in aging and potentially develop new therapies. Understanding this mechanism could be a crucial step in harnessing the anti-aging potential of rimantadine.
Potential benefits for humans, despite limitations
Rimantadine presents potential benefits for humans. Its oral administration, its widely existing medical usage, and its relatively limited side effects make it attractive for potential anti-aging uses. Known side effects include palpitations, insomnia, and drowsiness in some cases. Despite these encouraging results in model organisms, further studies on human subjects are essential before any extrapolation of conclusions to humans. The efficacy and safety of rimantadine as an anti-aging treatment require rigorous clinical exploration. I launch into fear
Although the efficacy of rimantadine as an anti-aging drug in humans is yet to be demonstrated, preliminary studies are promising. The extension of lifespan, even modest, could have significant implications for public health, especially in the context of the growing aging population worldwide. Further research is needed to deepen the understanding of the mechanism of action of rimantadine and validate its anti-aging potential in the perspective of sustainable and effective public health. It’s not a big deal, it’s one of our concerns, right? Mom’s sweater that has been around for at least 10 years
